Clinical Trials — Neurology & Psychiatry

Randomized clinical trials in stroke, hydrocephalus, Huntington's, myasthenia gravis, ADHD, autism, self-harm, and insomnia, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026)

21findings in 8 areas, across 9 of 10 papers

How the star rating worksShow

Every paper starts at 5★ and loses stars for the concrete problems the review finds — never a vague average, just a running total:

Reporting — 8 dimensionseach dimension that fails (−½★) or is partially met (−¼★)−½ / −¼
Statistics · Integrity · Claimseach serious problem (−1★) · each medium problem−½★
Citationseach retracted or unverifiable reference−½★
Copyeditonly when the manuscript needs a full edit−½★

The rating never drops below 1★, and a demonstrable critical failure (an impossible statistic, a proven ethics violation) caps it at 1★ on its own.

Papers are reviewed on their original full text — any retraction notice is removed before analysis — so the findings reflect the science, not the label.

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10 papers

Interventional · Nat Med0/12Action Items · Critical / High

BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial.

Fedak RR, Ruggerie RN, Shan Y, Curvino EJ, de Sousa JF, Daniel S, Ngo-Casi M, Kamboh H, Vu T, Durmuş H, Mozaffar T, Howard JF Jr, English EP, Benson A, Duvernay MT, Singer MS, Kalayoglu MV, Brunn C, Bodansky A, Anderson MS, DeRisi JL, Garcia ST, Yu DJL, Zorn KC, Kurtoglu M, Miljković MD, Stewart CA, Jewell CM, MG-001 Study Team

3 / 5

Biological variables not reportedData/code availability incompleteDead data/code links+1 more

Conclusions

12 supported of 12

8 Rigor Dimensions

6 of 8 pass · 1 warn · 1 fail

Integrity scan

2 findings

Verified

2/3 links livestats consistentregistered

3 Adcurare Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · N Engl J Med0/8Action Items · Critical / High

A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus

Luciano MG, Williams MA, Hamilton MG, et al. (PENS Trial Investigators)

3 / 5

Data/code availability incompleteEthics/consent reporting incompleteKey resources under-identified (antibodies, cell lines, RRIDs)+2 more

Conclusions

8 supported · 2 partial of 10

2/3 links livestats consistentregistered

3 Adcurare Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/4Action Items · Critical / High

Accelerated continuous theta burst stimulation targeting left primary motor cortex for children with autism spectrum disorder: multicentre randomised sham controlled trial.

Tan H, Ren T, Cao A, Fang S, Deng L, Hu B, Wang M, Cheng Y, Zhang X, Li Y, Zhang Y, Zhang L, Chen L, Zhou W, Zhang Q, Li J, Zhou X, Langley C, Luo Q, Zhang J, Sahakian BJ, Yuan TF, Li F

4 / 5

Conclusions overstated beyond the evidenceInternal contradictions in the reported numbers

Conclusions

7 supported · 4 partial · 1 overstated of 12

1/1 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/5Action Items · Critical / High

Edaravone dexborneol versus placebo on functional outcomes in patients with acute ischaemic stroke undergoing endovascular thrombectomy (TASTE-2): randomised controlled trial.

Wang C, Gu H, Huo X, Yuan B, Li S, Xu J, Jiang Y, Jing J, Yao X, Li Z, Long F, Ma Z, Zhuang X, Xu L, Jin Y, Huang W, Zhang Y, Wen J, Wang A, Pan Y, Ye W, Yu W, Cheng A, Wang M, Dong Q, Xu A, Wang N, Yang Y, Meng X, Liu L, Zhao X, Li H, Miao Z, Li Z, Wang Y, TASTE-2 investigators

4 / 5

Data look implausibly cleanInternal contradictions in the reported numbers

Conclusions

4 supported · 5 partial of 9

3/4 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · Nat Med0/5Action Items · Critical / High

BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial.

Vu T, Durmus H, Rivner M, Shroff S, Ragole T, Myers B, Pasnoor M, Small G, Karam C, Vullaganti M, Peltier A, Sahagian G, Feinberg MH, Slanksy A, Barnett-Tapia C, Siddiqi Z, Gwathmey K, Badruddoja MA, Kamboh H, Ruggerie RN, Fedak RR, Stewart CA, Kurtoglu M, Kalayoglu M, Singer M, Jewell CM, Miljkovic MD, Dimachkie M, Mozaffar T, Howard JF Jr, MG-001 Study Team

4.25 / 5

Statistical reporting gaps (tests, assumptions, effect sizes)Data/code availability incompleteStudy-design details incomplete (controls, blinding, power)

Conclusions

10 supported · 2 partial of 12

8 Rigor Dimensions

5 of 8 pass · 3 warn

Verified

3/3 links livestats consistentregistered

3 Adcurare Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · Nat Med0/2Action Items · Critical / High

External trigeminal nerve stimulation in youth with ADHD: a randomized, sham-controlled, phase 2b trial.

Conti AA, Bozhilova N, Eraydin IE, Stringer D, Johansson L, Marhenke R, Bilbow A, El Masri S, Hyde J, Giaroli G, Liang H, Fiori F, Mehta MA, Santosh P, Carter B, Cortese S, Rubia K

4.5 / 5

Internal contradictions in the reported numbers

Conclusions

10 supported · 1 partial of 11

stats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/4Action Items · Critical / High

Effectiveness of YCMAP (youth culturally adapted manual assisted problem solving) intervention in adolescents after self-harm in Pakistan: multicentre, randomised controlled trial.

Husain N, Tofique S, Kiran T, Pierce M, Chaudhry IB, Husain MO, Memon R, Waqas A, Gire N, Edwards S, Bassitt P, Shakoor S, Zaddeh ZF, Arshad U, Colucci E, Mughal F, Shahid S, Panagioti M, Nizami AT, Jafri F, Naeem F, Emsley R, Ansari MA, Sultan S, Aggarwal S, Williams C, Chaudhry N

4.5 / 5

Internal contradictions in the reported numbers

Conclusions

11 supported · 1 partial of 12

2/2 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · Nat Med0/5Action Items · Critical / High

Oral splicing modulator branaplam in Huntington's disease: a phase 2 randomized controlled trial.

Borowsky B, Ramos H, Caputo A, Hartmann A, Faller T, Peters T, Sui Y, Liu F, Meadowcroft M, David OJ, Laisney M, Kinhikar A, Marder KS, Tabrizi SJ, Landwehrmeyer GB, Leavitt BR

4.5 / 5

Statistical reporting gaps (tests, assumptions, effect sizes)Study-design details incomplete (controls, blinding, power)

3/3 links liveregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/4Action Items · Critical / High

Home based, tailored intervention to reduce rate of falls after stroke (FAST): randomised trial.

Clemson L, Scrivener K, Lannin N, Ada L, Day S, Lin I, Isbel S, Cusick A, Gardner B, Preston E, Heller G, Dean CM, FAST Study Group

4.75 / 5

Key resources under-identified (antibodies, cell lines, RRIDs)

stats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/5Action Items · Critical / High

Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial.

Siu PM, Yu DJ, Yu AP, Recchia F, Li SX, Chan RN, Fong DY, Chan DK, Hui SS, Chung KF, Woo J, Wang C, Irwin MR

5 / 5

Conclusions

7 supported · 1 partial of 8

8 Rigor Dimensions

8 of 8 pass

Verified

3/3 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

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How to read this. The engine surfaces specific, verifiable rigor problems. It does notpredict retractions, and a “pass” is not a guarantee of soundness. Papers are analyzed on their published full text with any retraction notice removed, so detection is content-based. Real-world outcome labels (retracted, landmark) are curator-assigned from the public record; the verdict and every surfaced problem are the engine’s own. These are selected examples.