Clinical Trials — Infectious Disease (Treatment)

6 supported · 2 partial of 8

3 of 8 pass · 3 warn · 2 fail

Integrity scan

4 findings2 medium

2 Adcurare Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · Nat Med0/8Action Items · Critical / High

Elebsiran and PEG-IFNα for chronic hepatitis B infection: a partially randomized, open-label, phase 2 trial

Wong GL, Yuen MF, Lin B, Douglas MW, Hu P, Xie Q, Lv F, Tak WY, Leerapun A, Kim DJ, Tangkijvanich P, Lim YS, Dai CY, O'Beirne J, Weltman M, Khemnark S, Piratvisuth T, Manasirisuk W, Chen X, Liu CJ, Heo J, Lee J, Niu J, Kumar R, Kumar R, Zhu C, Cao K, Tian A, Chen X, Zhu Q, Margolis D, Jia J, Hong Z.

3.25 / 5

Data and code not sharedKey resources under-identified (antibodies, cell lines, RRIDs)References not resolvable to a published paper

9 supported · 2 partial of 11

6 of 8 pass · 1 warn · 1 fail

1/1 links liveregistered

3 Adcurare Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · N Engl J Med0/6Action Items · Critical / High

Ciprofloxacin versus Aminoglycoside-Ciprofloxacin for Bubonic Plague.

Randremanana RV, Raberahona M, Bourner J, Rajerison M, Edwards T, Randriamparany R, Fehizoro Razafindratsinana T, Razananaivo LH, Zadonirina G, Mayouya-Gamana T, Salam APA, Mangahasimbola RT, Andrianaivoarimanana V, Pesonel E, Rakotoarivelo RA, Randria MJD, Horby P, Olliaro P, IMASOY Study Group

3.5 / 5

Data/code availability incompleteKey resources under-identified (antibodies, cell lines, RRIDs)References not resolvable to a published paper

6 supported · 1 partial of 7

6 of 8 pass · 2 warn

stats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · N Engl J Med0/3Action Items · Critical / High

Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo.

PALM007 Writing Group, Ali R, Alonga J, Biampata JL, Kombozi Basika M, Maljkovic Berry I, Bisento N, Blum E, Bonnett T, Cone K, Crozier I, Davey R, Dilu A, Dodd LE, Gulati I, Hruby D, Ibanda A, Isse F, Kasareka SS, Kayembe G, Kojan R, Luzolo EK, Lane HC, Lawanga L, Liesenborghs L, Shosongo Lunghe C, Lula Y, Lusakibanza M, Lutete GT, Mbala-Kingebeni P, Miranda A, Mukadi-Bamuleka D, Mukendi G, Lupola PM, Muyembe-Tamfum JJ, Ndungunu R, Nganga B, Ntamabyaliro N, Nussenblatt V, Omulepu I, Omalokoho Onosomba J, Proschan M, Rubenstein K, Saknite I, Schechner A, Shaw-Saliba K, Sivahera B, Smolskis M, Tillman A, Tkaczyk E, Tshimanga C, Tshiani Mbaya O, Tshomba A, Yemba Unda Tshomba F, Vallee D, Vogel S, Weyers S

3.75 / 5

Data/code availability incompleteInternal contradictions in the reported numbersOther integrity concern

10 supported · 2 partial of 12

1/2 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · BMJ0/5Action Items · Critical / High

Oral ivermectin versus 5% permethrin cream to treat children and adults with classic scabies: multicentre, assessor blinded, cluster randomised clinical trial.

Boralevi F, Simon G, Bernigaud C, Brun J, Goujon E, Perrot JL, Phan A, Hérissé AL, Maruani A, Vanhaecke C, Couty E, Abasq-Thomas C, Fournet M, Mallet S, Brenaut E, Hubiche T, Balguerie X, Caux F, Beneton N, Dutkiewicz AS, Adamski H, Aubert H, Bourrat E, Couzan C, Eyraud A, Janela-Lapert R, Marti A, Miquel J, Richard M, Barbarot S, Bonniaud B, Chabbert C, Delion F, Dinulescu M, Duong TA, Etienne M, Hirsch G, Isnard C, Huet F, Le Bidre E, Leducq S, Legrand A, Monestier S, Morice-Picard F, Seneschal J, Capelli A, Lacoste C, Labrèze C, Miraglia G, Do-Pham G, Giraudeau B, Chosidow O

3.75 / 5

Internal contradictions in the reported numbersData look implausibly cleanReferences not resolvable to a published paper

9 supported · 2 partial of 11

1/1 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · N Engl J Med0/7Action Items · Critical / High

Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis.

Meya DB, Cresswell FV, Dai B, Engen N, Naidoo K, Ganiem AR, Imran D, Kabahubya M, Lessells RJ, Yunivita V, Estiasari R, Tugume L, Hlabisa B, Kurniawati MY, Sagita N, Kagimu E, Maharani K, Gakuru J, Gaharu MN, Mugabi T, Kimuda S, Namombwe S, Te Brake L, Aarnoutse R, Svensson EM, Bangdiwala AS, Namanda S, Bahr NC, Musubire AK, Moosa MYS, Hamers RL, Marais S, Boulware DR, van Crevel R, Ruslami R, HARVEST Trial Team

3.75 / 5

Data/code availability incompleteImplausibly large reported effectInternal contradictions in the reported numbers

10 supported · 2 partial of 12

stats consistentregistered

3 Adcurare Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · N Engl J Med0/4Action Items · Critical / High

Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model.

Durbin AP, Van Wesenbeeck L, Pierce KK, Herrera-Taracena G, Ebone L, Buelens A, Lutton P, Sabundayo BP, Van Eygen V, De Clerck K, Fetter I, Voge NV, Fang X, Goeyvaerts N, Vandendijck Y, Mayfield J, Lenz O, De Meyer S, Kakuda TN, He H, Amaro-Carambot E, Akli RD, Carmolli M, De Marez T, Whitehead SS, Van Loock M, Rasschaert F

4 / 5

Data and code not sharedStatistical reporting gaps (tests, assumptions, effect sizes)Ethics/consent reporting incomplete

9 supported · 2 partial of 11

5 of 8 pass · 2 warn · 1 fail

2/2 links liveregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · N Engl J Med0/7Action Items · Critical / High

Oral Nirmatrelvir-Ritonavir for Covid-19 in Higher-Risk Outpatients.

Butler CC, Pinto AD, Harris V, Holmes J, Rahman NM, Cureton L, Hayward G, Richards DB, Lowe DM, Standing JF, Breuer J, Hood K, Png ME, Petrou S, Dorward J, Patel MG, Thomas NPB, Evans P, Hart ND, Jani BD, Hosseini B, Murthy S, McBrien K, Condon A, McDonald EG, Daley P, Greiver M, da Costa BR, Selby P, Jüni P, Lee TC, Shi H, Detry MA, Saunders CT, Fitzgerald M, Berry NS, Saville BR, Khoo SH, Nguyen-Van-Tam JS, Hobbs FDR, Yu LM, Little P, PANORAMIC Trial and CanTreatCOVID Trial Collaborative Groups

4 / 5

Data and code not sharedInternal contradictions in the reported numbers

1/2 links liveregistered

3 Adcurare Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · Lancet0/4Action Items · Critical / High

Zoliflodacin versus ceftriaxone plus azithromycin for treatment of uncomplicated urogenital gonorrhoea: an international, randomised, controlled, open-label, phase 3, non-inferiority clinical trial

Luckey A, Balasegaram M, Barbee LA, et al. (Zoliflodacin Phase 3 Study Group)

4 / 5

References not resolvable to a published paper

6 supported · 3 partial of 9

8 of 8 pass

3/3 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · N Engl J Med0/6Action Items · Critical / High

Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis.

Guglielmetti L, Khan U, Velásquez GE, Gouillou M, Abubakirov A, Baudin E, Berikova E, Berry C, Bonnet M, Cellamare M, Chavan V, Cox V, Dakenova Z, de Jong BC, Ferlazzo G, Karabayev A, Kirakosyan O, Kiria N, Kunda M, Lachenal N, Lecca L, McIlleron H, Motta I, Toscano SM, Mushtaque H, Nahid P, Oyewusi L, Panda S, Patil S, Phillips PPJ, Ruiz J, Salahuddin N, Garavito ES, Seung KJ, Ticona E, Trippa L, Vasquez DEV, Wasserman S, Rich ML, Varaine F, Mitnick CD, endTB Clinical Trial Team

4.25 / 5

Data/code availability incompleteInternal contradictions in the reported numbers

2/2 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · N Engl J Med0/3Action Items · Critical / High

Second-Line Antiretroviral Therapy for Children Living with HIV in Africa.

Musiime V, Bwakura-Dangarembizi M, Szubert AJ, Mumbiro V, Mujuru HA, Kityo CM, Lugemwa A, Doerholt K, Chabala C, Makumbi S, Mulenga V, McIlleron H, Burger D, Natukunda E, Shakeshaft C, Linda KJ, Nathoo K, Monkiewicz L, Yawe I, Kapasa M, Nyathi M, Lungu J, Nduna B, Ndebele W, South A, Mwamabazi M, Musoro G, Griffiths A, Zyambo K, Nazzinda R, Zimba K, Zhang Y, Walker S, Turkova A, Walker AS, Bamford A, Gibb DM, CHAPAS-4 Trial Team

4.25 / 5

Data/code availability incompleteReferences not resolvable to a published paper

11 supported · 1 partial of 12

7 of 8 pass · 1 warn

1/2 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Summary statistic impossible for the stated N (GRIM/GRIMMER)

Interventional · Nat Med

Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial.

Donovan J, Duc Bang N, Dong HKT, Ho DTN, Nguyen TAT, Nguyen TTH, Lam HBN, Phung VKN, Nguyen TT, Nguyen HHH, Pham KNO, Do DAT, Nguyen TMT, Dang TMH, Nguyen HL, Nguyen VVC, Hoang TH, Tran DD, Phung KL, Ramakrishnan L, Le THN, Nguyen TTT, Wolbers M, Kestelyn E, Geskus RB, Nguyen HP, Thwaites GE

4.5 / 5

11 supported · 1 partial of 12

8 of 8 pass

2/2 links live1 impossible statregistered

3 Adcurare Rigor ReviewersAI Rigor Reviewers trained on Adcurare corpus · verify findings

Interventional · Nat Med0/3Action Items · Critical / High

Mass azithromycin distribution and antibiotic resistance in the gut and nasopharynx: a cluster-randomized trial.

Doan T, Yan D, Arzika AM, Abdou A, Maliki R, Aichatou B, Bello IM, Beidi D, Galo N, Harouna N, Karamba AM, Mahamadou S, Abarchi M, Ibrahim A, Zhong L, Chen C, Liu Y, Yu D, Abraham T, Cheng AS, Peterson B, Oldenburg CE, Porco TC, Arnold BF, Hinterwirth A, Lebas E, O'Brien KS, Lietman TM

4.75 / 5

Dead data/code links

11 supported · 1 partial of 12

8 of 8 pass

3/6 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings