Clinical Trials — Respiratory

Randomized clinical trials in pulmonary disease — idiopathic pulmonary fibrosis, neonatal ventilation, pneumonia, and lung-nodule diagnosis, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026)

7findings in 2 areas, across 3 of 4 papers

How the star rating worksShow

Every paper starts at 5★ and loses stars for the concrete problems the review finds — never a vague average, just a running total:

Reporting — 8 dimensionseach dimension that fails (−½★) or is partially met (−¼★)−½ / −¼
Statistics · Integrity · Claimseach serious problem (−1★) · each medium problem−½★
Citationseach retracted or unverifiable reference−½★
Copyeditonly when the manuscript needs a full edit−½★

The rating never drops below 1★, and a demonstrable critical failure (an impossible statistic, a proven ethics violation) caps it at 1★ on its own.

Papers are reviewed on their original full text — any retraction notice is removed before analysis — so the findings reflect the science, not the label.

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4 papers · 1 critical

Interventional · N Engl J Med0/0Action Items · Critical / High

A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia.

Lucinde RK, Gathuri H, Mwaniki P, Orindi B, Otieno EO, Mwakio S, Mulemi L, Isaaka L, Shangala J, Saisi M, Isinde E, Oginga IN, Wachira AW, Manuthu E, Kariuki H, Asaava P, Nyikuli J, Wekesa C, Otedo A, Bosire H, Okoth SB, Ongalo W, Mukabi DM, Lusamba W, Muthui B, Adembesa I, Mithi C, Sood M, Aliyan NA, Gituma B, Matiko MG, Omondi CA, Ombajo LA, Kirui N, Ochola L, Abdi AI, Kagucia EW, English M, Hamaluba M, Ochola-Oyier I, Kamuya D, Bejon P, Barasa E, Agweyu A, Akech S, Etyang AO

1.5 / 5

Data/code availability incompleteDead data/code linksInternal contradictions in the reported numbers

1/4 links livestats consistentregistered

3 Adcurare Rigor ReviewersAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · N Engl J Med0/7Action Items · Critical / High

Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules.

Lentz RJ, Frederick-Dyer K, Planz VB, Koyama T, Aboudara MC, Avasarala SK, Casey JD, Cheng GZ, D'Haese PF, Duke JD, Grogan EL, Hoopman TC, Johnson J, Katsis JM, Kurman JS, Low SW, Mahmood K, Rickman OB, Roller L, Salmon C, Shojaee S, Swanner B, Wahidi MM, Walston C, Silvestri GA, Yarmus L, Rahman NM, Maldonado F, Interventional Pulmonary Outcomes Group

3.5 / 5

Data and code not sharedInternal contradictions in the reported numbersOther integrity concern

Conclusions

8 supported · 1 partial of 9

2/2 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · Nat Med0/6Action Items · Critical / High

A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Xu Z, Ren F, Wang P, Cao J, Tan C, Ma D, Zhao L, Dai J, Ding Y, Fang H, Li H, Liu H, Luo F, Meng Y, Pan P, Xiang P, Xiao Z, Rao S, Satler C, Liu S, Lv Y, Zhao H, Chen S, Cui H, Korzinkin M, Gennert D, Zhavoronkov A.

3.5 / 5

Internal contradictions in the reported numbers

Conclusions

10 supported · 2 partial of 12

6/6 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/2Action Items · Critical / High

Non-invasive high frequency oscillatory ventilation for primary respiratory support in extremely preterm infants: multicentre randomised controlled trial

Li Y, Zhu X, Li LJ, Chen L, Yang Q, Xu L, Liang W, Lin X, Li C, Xue J, Liu L, Pan X, Ju R, Peng X, Tang W, Shi Y, NHFOV study group.

5 / 5

Conclusions

11 supported · 1 partial of 12

8 Rigor Dimensions

8 of 8 pass

Verified

1/1 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

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How to read this. The engine surfaces specific, verifiable rigor problems. It does notpredict retractions, and a “pass” is not a guarantee of soundness. Papers are analyzed on their published full text with any retraction notice removed, so detection is content-based. Real-world outcome labels (retracted, landmark) are curator-assigned from the public record; the verdict and every surfaced problem are the engine’s own. These are selected examples.