Clinical Trials — Other

Randomized clinical trials in ophthalmology and gastrointestinal microbiome trials, from NEJM · Lancet · Nature Medicine · BMJ (2024–2026)

2findings in 2 areas, across 2 of 2 papers

How the star rating worksShow

Every paper starts at 5★ and loses stars for the concrete problems the review finds — never a vague average, just a running total:

Reporting — 8 dimensionseach dimension that fails (−½★) or is partially met (−¼★)−½ / −¼
Statistics · Integrity · Claimseach serious problem (−1★) · each medium problem−½★
Citationseach retracted or unverifiable reference−½★
Copyeditonly when the manuscript needs a full edit−½★

The rating never drops below 1★, and a demonstrable critical failure (an impossible statistic, a proven ethics violation) caps it at 1★ on its own.

Papers are reviewed on their original full text — any retraction notice is removed before analysis — so the findings reflect the science, not the label.

Sort

2 papers

Interventional · BMJ0/0Action Items · Critical / High

Low concentration atropine eye drops and progression of myopia in children: multicentre placebo controlled, double masked, randomised trial in the UK (CHAMP-UK).

Azuara-Blanco A, Logan NS, McConnell E, Kearney S, Kirk G, Jones S, McDowell C, Murphy L, O'Hanlon G, McFarland M, Painter S, Muthusamy B, Nabili S, Preston J, Flitcroft I, Loughman J, Mackey D, Lee S, Dahlmann-Noor A, Congdon N, Hogg RE, Hammond CJ, Saunders K, Allen PM, Strang N, Clarke M

4 / 5

Internal contradictions in the reported numbers

Conclusions

11 supported · 1 partial of 12

2/3 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · Nat Med0/7Action Items · Critical / High

The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome.

Bryant JA, Vulić M, Walsh EA, Allen EG Jr, Beauchemin NJ, Chafee ME, Diao L, Fenn K, Ford KA, Hasson BR, Litcofsky KD, Lombardo MJ, Martinez A, O'Brien EJ, Straub TJ, Sykes SM, Marshall LF, Winkler JA, McGovern BH, Ford CB, Wortman JR, Henn MR

4.75 / 5

Data/code availability incomplete

Conclusions

11 supported · 1 partial of 12

8 Rigor Dimensions

7 of 8 pass · 1 warn

Verified

2/2 links liveregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Share this gallery with your network

Post on X Share on LinkedIn Share via Email

How to read this. The engine surfaces specific, verifiable rigor problems. It does notpredict retractions, and a “pass” is not a guarantee of soundness. Papers are analyzed on their published full text with any retraction notice removed, so detection is content-based. Real-world outcome labels (retracted, landmark) are curator-assigned from the public record; the verdict and every surfaced problem are the engine’s own. These are selected examples.