Clinical Trials — Obstetrics, Reproductive & Neonatal

Randomized clinical trials in pregnancy, fertility, and newborn care (gestational diabetes, postpartum haemorrhage, IVF, breastfeeding, neonatal care), from NEJM · Lancet · Nature Medicine · BMJ (2024–2026)

12findings in 7 areas, across 5 of 8 papers

How the star rating worksShow

Every paper starts at 5★ and loses stars for the concrete problems the review finds — never a vague average, just a running total:

Reporting — 8 dimensionseach dimension that fails (−½★) or is partially met (−¼★)−½ / −¼
Statistics · Integrity · Claimseach serious problem (−1★) · each medium problem−½★
Citationseach retracted or unverifiable reference−½★
Copyeditonly when the manuscript needs a full edit−½★

The rating never drops below 1★, and a demonstrable critical failure (an impossible statistic, a proven ethics violation) caps it at 1★ on its own.

Papers are reviewed on their original full text — any retraction notice is removed before analysis — so the findings reflect the science, not the label.

Sort

8 papers

Interventional · BMJ0/4Action Items · Critical / High

Time restricted eating and exercise training before and during pregnancy for people with increased risk of gestational diabetes: single centre randomised controlled trial (BEFORE THE BEGINNING)

Sujan MJ, Skarstad HM, Rosvold G, Fougner SL, Follestad T, Salvesen KÅ, Moholdt T.

3.5 / 5

Summary statistic impossible for the stated N (GRIM/GRIMMER)Key resources under-identified (antibodies, cell lines, RRIDs)Study-design details incomplete (controls, blinding, power)+1 more

2/2 links live1 impossible statregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · Lancet

Effectiveness of kangaroo mother care before clinical stabilisation versus standard care among neonates at five hospitals in Uganda (OMWaNA): a parallel-group, individually randomised controlled trial and economic evaluation.

Tumukunde V, Medvedev MM, Tann CJ, Mambule I, Pitt C, Opondo C, Kakande A, Canter R, Haroon Y, Kirabo-Nagemi C, Abaasa A, Okot W, Katongole F, Ssenyonga R, Niombi N, Nanyunja C, Elbourne D, Greco G, Ekirapa-Kiracho E, Nyirenda M, Allen E, Waiswa P, Lawn JE, OMWaNA Collaborative Authorship Group

3.75 / 5

Data/code availability incompleteReferences not resolvable to a published paper

stats consistentregistered

2 Adcurare Rigor ReviewersAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · N Engl J Med0/6Action Items · Critical / High

A Multicomponent Intervention to Improve Maternal Infection Outcomes.

Lissauer D, Gadama L, Waitt C, Whyte S, Burnside G, Anilkumar A, Makuluni R, Okwaro P, Yang L, Waitt P, Musopole O, Bilesi R, Maseko B, Lwasa J, Mugahi R, Olaro C, Lamorde M, Makuta M, Kachiwaya C, Mkandawire T, Malunga A, Chitsulo N, Abitimo P, Ayabo T, Weeks A, Martin J, Hemming K, Gallos I, Monk EJM, Riches J, Chapuma C, Nanyondo S J, Lorencatto F, Monahan M, Allegranzi B, Dunlop C, Atkins L, Rosala-Hallas A, Roberts T, Gamble C, Malata A, Desmond N, Kommwa E, Merriel A, Parry-Smith W, Smith R, Ndumu I, Williams E, Faque B, Banda G, Nyondo-Mipando AL, Twimukye A, Chater T, Diplas A, Brizuela V, Souza JP, Rylance J, Cheshire J, Hawker L, Coomarasamy A, Bonet M

4 / 5

Biological variables underreported (sex, age, strain)Data/code availability incompleteEthics/consent reporting incomplete+1 more

stats consistentregistered

3 Adcurare Rigor Reviewers · moderate confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

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Interventional · BMJ0/3Action Items · Critical / High

Peer support intervention (ABA-feed) to improve breastfeeding: UK based, multicentre, parallel group, randomised controlled trial.

Jolly K, Clarke J, Crossland N, Dombrowski SU, Gkini E, Hoddinott P, Ingram J, Johnson D, MacArthur C, Mann M, McKell J, Moss N, Roberts T, Sanders J, Savory N, Sitch A, Taylor B, Tearne S, Thomson G, Williams E, Woolley R, ABA-feed study group

4.75 / 5

Data/code availability incomplete

Conclusions

11 supported · 1 partial of 12

8 Rigor Dimensions

7 of 8 pass · 1 warn

Verified

1/1 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/4Action Items · Critical / High

Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo controlled, phase 3 trial.

Zhang L, Bi S, Chen L, Du L, He F, Qiao Y, Li Z, Zeng W, Zhao X, Chen X, Li X, Ding G, Zhou W, Sun B, Guo Q, Guo X, Jin F, Wang X, Zhu Q, Sun Q, Jiang S, Wang X, Cai F, Jiang Y, Gao J, Wang Z, Wang Z, Zhang L, Liu JM, Huang L, Yu L, Chen J, Zhang S, Poon LC, Li HT, Chen D, study’s collaborator group

4.75 / 5

Data/code availability incomplete

Conclusions

9 supported · 3 partial of 12

8 Rigor Dimensions

7 of 8 pass · 1 warn

Verified

1/1 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/2Action Items · Critical / High

Risk of infection and wound dehiscence after use of prophylactic antibiotics in episiotomy or second degree tear (REPAIR study): single centre, double blind, placebo controlled randomised trial.

Perslev K, Klarskov N, Bergholt T, Jangö H

5 / 5

Conclusions

7 supported · 3 partial of 10

8 Rigor Dimensions

8 of 8 pass

Verified

2/2 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/0Action Items · Critical / High

Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.

Hu KL, Liao T, Wu Q, Ma X, Cao Y, Tan J, Tian L, Wang J, Yin J, Liu Y, Zhao J, Zhao S, Li M, Cai L, Liu FT, Gan K, Xu Y, Wang Y, Cai J, Zheng B, Ma Y, Ma Q, Zheng J, Pu X, Zhang H, Hao C, Xie Q, Zhang C, Jiang L, Zhang S, Yan L, Meng Q, Li W, Mol BW, Li R, Wang R, Zhang D, VitD-PCOS trial group

3/3 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

Interventional · BMJ0/5Action Items · Critical / High

Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial.

Wei D, Qin Y, Sun Y, Yan J, Zhao H, Guan Y, Tan J, Guo T, Wang Z, Gong F, Hao C, Ma X, Zhang C, Zhang A, Geng L, Sun M, Li X, Ling X, Lu Q, Bao H, Chao L, Huang W, Shi Q, Zhao J, Lu Y, Wu S, Zhang S, Wang J, Guo M, Sun X, Ma Y, Wu Q, Li Y, Ou X, Fang Z, Chen J, Hao G, Zhang H, Legro RS, Chen ZJ, PnROVE Study Group

1/1 links livestats consistentregistered

3 Adcurare Rigor Reviewers · high confidenceAI Rigor Reviewers trained on Adcurare corpus · verify findings

Read paperPMC Journal

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How to read this. The engine surfaces specific, verifiable rigor problems. It does notpredict retractions, and a “pass” is not a guarantee of soundness. Papers are analyzed on their published full text with any retraction notice removed, so detection is content-based. Real-world outcome labels (retracted, landmark) are curator-assigned from the public record; the verdict and every surfaced problem are the engine’s own. These are selected examples.